Utrecht and Eindhoven regions belong to the most competitive regions in Europe. The further development of a joint high-level science and technology infrastructure contributes to the competitiveness of both regions. Some years ago, Utrecht Medical Center, Eindhoven University of Technology and Utrecht University joined forces in a strategic Alliance: they strengthen both existing cooperations and complementary areas in education, research and valorisation. The strategic Alliance goes beyond knowledge exchange. It also aims to increase the succes rates in national and European reseach and infrastructural funding schemes and to enhance the national and international visibility. In the combination of UU’s famous fundamental research, Eindhoven’s advanced technological background and UMC’s medical expertise lies the key to success in the fields of solar fuels, regenerative medicine and non-invasive imaging techniques. These three fields are now complemented with the Darcy Center for Porous Media Science and Technology.